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U937 cells are a model cell line used in biomedical research.〔(【引用サイトリンク】 url = http://www.copewithcytokines.de/cope.cgi?key=U937 )〕 They were isolated from the histiocytic lymphoma of a 37-year-old male patient and are used to study the behaviour and differentiation of monocytes. U937 cells mature and differentiate in response to a number of soluble stimuli, adopting the morphology and characteristics of mature macrophages. U937 cells are of the myeloid lineage and so secrete a large number of cytokines and chemokines either constitutively (e.g. IL-1 and GM-CSF) or in response to soluble stimuli. TNFα and recombinant GM-CSF independently promote IL-10 production in U937 cells. IFNγ increases the expression of chemokine receptors (CCR1, CCR3 and CCR5) as well as that of nuclear receptors for melatonin. IFNγ treatment enhances thrombin-induced IL-8 production and is required for the melatonin-induced production of IL-6. U937 can be grown in DMEM or 1640 medium plus 10% fetal bovine serum. Atromentin induces apoptosis in human leukemia U937 cells.〔Atromentin-Induced Apoptosis in Human Leukemia U937 Cells. Kim Jin Hee and Choong Hwan Lee, Journal of microbiology and biotechnology, 2009, vol. 19, no9, pages 946-950, 〕 The HLA alleles present in U937 cells are HLA-A *03:01, A *31:01, B *18:01, B *51:01, Cw *01:02 and Cw *07:02. == References == ==External links== *(Cellosaurus entry for U937 ) 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「U937 cell」の詳細全文を読む スポンサード リンク
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